Tim Anderson led off with a home run, Dallas Keuchel pitched five strong innings and the Chicago White Sox edged the host Boston Red Sox 3-2 in Game 1 of a split doubleheader Sunday afternoon.

Anderson finished 3-for-4 as the White Sox snapped a two-game skid. Keuchel (1-0) gave up two runs on six hits, walking none and striking out one.

Liam Hendriks worked around a two-out single in the bottom of the seventh for his second save.

Enrique Hernandez homered, and Bobby Dalbec finished with a pair of hits for the Red Sox, who lost for just the second time in their past 12 games.

Sunday's doubleheader was scheduled after Friday's series opener between the clubs was postponed by snow and rain in the Boston area. The makeup is Game 2, set to begin at 5:10 p.m. ET.

Anderson wasted no time putting Chicago ahead in Game 1, blasting the first pitch delivered by Boston starter Tanner Houck the opposite way into the bullpen for his second homer of the season. The score remained 1-0 until Yasmani Grandal doubled home Jose Abreu with two outs in the top of the fourth inning for a 2-0 advantage.

The Red Sox got on the board in the bottom of the frame. With runners on first and third and two outs, Hunter Renfroe hit an infield chopper that eluded Moncada at third base to drive in J.D. Martinez. Renfroe would be picked off trying to advance to second to end the threat.

A Moncada RBI single in the top of the fifth gave the White Sox key insurance as Hernandez led off the bottom of the sixth with a home run off Keuchel tucked around the right field foul pole to get Boston within 3-2. Aaron Bummer took over on the mound, and after an Alex Verdugo single, got a double play and a strikeout to end the inning.

Houck (0-2) allowed three runs on six hits over 4 1/3 innings, walking none and striking out two.